diff --git a/openfpga_flow/openfpga_arch/README.md b/openfpga_flow/openfpga_arch/README.md
index 0960d3f2d..cdd8db5f3 100644
--- a/openfpga_flow/openfpga_arch/README.md
+++ b/openfpga_flow/openfpga_arch/README.md
@@ -18,7 +18,7 @@ Note that an OpenFPGA architecture can be applied to multiple VPR architecture f
 - aib: If the Advanced Interface Bus (AIB) is used in place of some I/Os.
 - <bank\|cc\|frame\|standalone>: specify the type of configuration protocol used in the architecture.
   - `bank` refers to the memory bank
-  - `cc` refers to the configuration chain
+  - `cc` refers to the configuration chain. Note that a postfix `<int>clk` may be applied when the configuration chain is controlled by more than 1 clocks
   - `frame` refers to the frame-based organization
   - `standalone` referes to the vanilla organization
 - fixed\_sim: fixed clock frequencies in simulation settings. If auto clock frequencies are used, there is no need to appear in the naming
diff --git a/openfpga_flow/openfpga_arch/k4_N4_40nm_multi_region_cc2clk_openfpga.xml b/openfpga_flow/openfpga_arch/k4_N4_40nm_multi_region_cc2clk_openfpga.xml
new file mode 100644
index 000000000..8f546cca2
--- /dev/null
+++ b/openfpga_flow/openfpga_arch/k4_N4_40nm_multi_region_cc2clk_openfpga.xml
@@ -0,0 +1,194 @@
+<?xml version="1.0"?>
+<!-- Architecture annotation for OpenFPGA framework
+     This annotation supports the k6_N10_40nm.xml 
+     - General purpose logic block
+       - K = 6, N = 10, I = 40
+       - Single mode
+     - Routing architecture
+       - L = 4, fc_in = 0.15, fc_out = 0.1
+  -->
+<openfpga_architecture>
+  <technology_library>
+    <device_library>
+      <device_model name="logic" type="transistor">
+        <lib type="industry" corner="TOP_TT" ref="M" path="${OPENFPGA_PATH}/openfpga_flow/tech/PTM_45nm/45nm.pm"/>
+        <design vdd="0.9" pn_ratio="2"/>
+        <pmos name="pch" chan_length="40e-9" min_width="140e-9" variation="logic_transistor_var"/>
+        <nmos name="nch" chan_length="40e-9" min_width="140e-9" variation="logic_transistor_var"/>
+      </device_model>
+      <device_model name="io" type="transistor">
+        <lib type="academia" ref="M" path="${OPENFPGA_PATH}/openfpga_flow/tech/PTM_45nm/45nm.pm"/>
+        <design vdd="2.5" pn_ratio="3"/>
+        <pmos name="pch_25" chan_length="270e-9" min_width="320e-9" variation="io_transistor_var"/>
+        <nmos name="nch_25" chan_length="270e-9" min_width="320e-9" variation="io_transistor_var"/>
+      </device_model>
+    </device_library>
+    <variation_library>
+      <variation name="logic_transistor_var" abs_deviation="0.1" num_sigma="3"/>
+      <variation name="io_transistor_var" abs_deviation="0.1" num_sigma="3"/>
+    </variation_library>
+  </technology_library>
+  <circuit_library>
+    <circuit_model type="inv_buf" name="INVTX1" prefix="INVTX1" is_default="true">
+      <design_technology type="cmos" topology="inverter" size="1"/>
+      <device_technology device_model_name="logic"/>
+      <port type="input" prefix="in" size="1"/>
+      <port type="output" prefix="out" size="1"/>
+      <delay_matrix type="rise" in_port="in" out_port="out">
+        10e-12
+      </delay_matrix>
+      <delay_matrix type="fall" in_port="in" out_port="out">
+        10e-12
+      </delay_matrix>
+    </circuit_model>
+    <circuit_model type="inv_buf" name="buf4" prefix="buf4" is_default="false">
+      <design_technology type="cmos" topology="buffer" size="1" num_level="2" f_per_stage="4"/>
+      <device_technology device_model_name="logic"/>
+      <port type="input" prefix="in" size="1"/>
+      <port type="output" prefix="out" size="1"/>
+      <delay_matrix type="rise" in_port="in" out_port="out">
+        10e-12
+      </delay_matrix>
+      <delay_matrix type="fall" in_port="in" out_port="out">
+        10e-12
+      </delay_matrix>
+    </circuit_model>
+    <circuit_model type="inv_buf" name="tap_buf4" prefix="tap_buf4" is_default="false">
+      <design_technology type="cmos" topology="buffer" size="1" num_level="3" f_per_stage="4"/>
+      <device_technology device_model_name="logic"/>
+      <port type="input" prefix="in" size="1"/>
+      <port type="output" prefix="out" size="1"/>
+      <delay_matrix type="rise" in_port="in" out_port="out">
+        10e-12
+      </delay_matrix>
+      <delay_matrix type="fall" in_port="in" out_port="out">
+        10e-12
+      </delay_matrix>
+    </circuit_model>
+    <circuit_model type="pass_gate" name="TGATE" prefix="TGATE" is_default="true">
+      <design_technology type="cmos" topology="transmission_gate" nmos_size="1" pmos_size="2"/>
+      <device_technology device_model_name="logic"/>
+      <input_buffer exist="false"/>
+      <output_buffer exist="false"/>
+      <port type="input" prefix="in" size="1"/>
+      <port type="input" prefix="sel" size="1"/>
+      <port type="input" prefix="selb" size="1"/>
+      <port type="output" prefix="out" size="1"/>
+      <delay_matrix type="rise" in_port="in sel selb" out_port="out">
+        10e-12 5e-12 5e-12
+      </delay_matrix>
+      <delay_matrix type="fall" in_port="in sel selb" out_port="out">
+        10e-12 5e-12 5e-12
+      </delay_matrix>
+    </circuit_model>
+    <circuit_model type="chan_wire" name="chan_segment" prefix="track_seg" is_default="true">
+      <design_technology type="cmos"/>
+      <input_buffer exist="false"/>
+      <output_buffer exist="false"/>
+      <port type="input" prefix="in" size="1"/>
+      <port type="output" prefix="out" size="1"/>
+      <wire_param model_type="pi" R="101" C="22.5e-15" num_level="1"/>
+      <!-- model_type could be T, res_val and cap_val DON'T CARE -->
+    </circuit_model>
+    <circuit_model type="wire" name="direct_interc" prefix="direct_interc" is_default="true">
+      <design_technology type="cmos"/>
+      <input_buffer exist="false"/>
+      <output_buffer exist="false"/>
+      <port type="input" prefix="in" size="1"/>
+      <port type="output" prefix="out" size="1"/>
+      <wire_param model_type="pi" R="0" C="0" num_level="1"/>
+      <!-- model_type could be T, res_val cap_val should be defined -->
+    </circuit_model>
+    <circuit_model type="mux" name="mux_tree" prefix="mux_tree" dump_structural_verilog="true">
+      <design_technology type="cmos" structure="tree" add_const_input="true" const_input_val="1"/>
+      <input_buffer exist="true" circuit_model_name="INVTX1"/>
+      <output_buffer exist="true" circuit_model_name="INVTX1"/>
+      <pass_gate_logic circuit_model_name="TGATE"/>
+      <port type="input" prefix="in" size="1"/>
+      <port type="output" prefix="out" size="1"/>
+      <port type="sram" prefix="sram" size="1"/>
+    </circuit_model>
+    <circuit_model type="mux" name="mux_tree_tapbuf" prefix="mux_tree_tapbuf" is_default="true" dump_structural_verilog="true">
+      <design_technology type="cmos" structure="tree" add_const_input="true" const_input_val="1"/>
+      <input_buffer exist="true" circuit_model_name="INVTX1"/>
+      <output_buffer exist="true" circuit_model_name="tap_buf4"/>
+      <pass_gate_logic circuit_model_name="TGATE"/>
+      <port type="input" prefix="in" size="1"/>
+      <port type="output" prefix="out" size="1"/>
+      <port type="sram" prefix="sram" size="1"/>
+    </circuit_model>
+    <!--DFF subckt ports should be defined as <D> <Q> <CLK> <RESET> <SET>  -->
+    <circuit_model type="ff" name="DFFSRQ" prefix="DFFSRQ" spice_netlist="${OPENFPGA_PATH}/openfpga_flow/openfpga_cell_library/spice/dff.sp" verilog_netlist="${OPENFPGA_PATH}/openfpga_flow/openfpga_cell_library/verilog/dff.v">
+      <design_technology type="cmos"/>
+      <input_buffer exist="true" circuit_model_name="INVTX1"/>
+      <output_buffer exist="true" circuit_model_name="INVTX1"/>
+      <port type="input" prefix="D" size="1"/>
+      <port type="input" prefix="set" lib_name="SET" size="1" is_global="true" default_val="0" is_set="true"/>
+      <port type="input" prefix="reset" lib_name="RST" size="1" is_global="true" default_val="0" is_reset="true"/>
+      <port type="output" prefix="Q" size="1"/>
+      <port type="clock" prefix="clk" lib_name="CK" size="1" is_global="true" default_val="0"/>
+    </circuit_model>
+    <circuit_model type="lut" name="lut4" prefix="lut4" dump_structural_verilog="true">
+      <design_technology type="cmos"/>
+      <input_buffer exist="true" circuit_model_name="INVTX1"/>
+      <output_buffer exist="true" circuit_model_name="INVTX1"/>
+      <lut_input_inverter exist="true" circuit_model_name="INVTX1"/>
+      <lut_input_buffer exist="true" circuit_model_name="buf4"/>
+      <pass_gate_logic circuit_model_name="TGATE"/>
+      <port type="input" prefix="in" size="4"/>
+      <port type="output" prefix="out" size="1"/>
+      <port type="sram" prefix="sram" size="16"/>
+    </circuit_model>
+    <!--Scan-chain DFF subckt ports should be defined as <D> <Q> <Qb> <CLK> <RESET> <SET>  -->
+    <circuit_model type="ccff" name="DFF" prefix="DFF" spice_netlist="${OPENFPGA_PATH}/openfpga_flow/openfpga_cell_library/spice/dff.sp" verilog_netlist="${OPENFPGA_PATH}/openfpga_flow/openfpga_cell_library/verilog/dff.v">
+      <design_technology type="cmos"/>
+      <input_buffer exist="true" circuit_model_name="INVTX1"/>
+      <output_buffer exist="true" circuit_model_name="INVTX1"/>
+      <port type="input" prefix="D" size="1"/>
+      <port type="output" prefix="Q" size="1"/>
+      <port type="output" prefix="QN" size="1"/>
+      <port type="clock" prefix="prog_clk" lib_name="CK" size="1" is_global="true" default_val="0" is_prog="true"/>
+    </circuit_model>
+    <circuit_model type="iopad" name="GPIO" prefix="GPIO" spice_netlist="${OPENFPGA_PATH}/openfpga_flow/openfpga_cell_library/spice/gpio.sp" verilog_netlist="${OPENFPGA_PATH}/openfpga_flow/openfpga_cell_library/verilog/gpio.v">
+      <design_technology type="cmos"/>
+      <input_buffer exist="true" circuit_model_name="INVTX1"/>
+      <output_buffer exist="true" circuit_model_name="INVTX1"/>
+      <port type="inout" prefix="PAD" size="1" is_global="true" is_io="true" is_data_io="true"/>
+      <port type="sram" prefix="DIR" size="1" mode_select="true" circuit_model_name="DFF" default_val="1"/>
+      <port type="input" prefix="outpad" lib_name="A" size="1"/>
+      <port type="output" prefix="inpad" lib_name="Y" size="1"/>
+    </circuit_model>
+  </circuit_library>
+  <configuration_protocol>
+    <organization type="scan_chain" circuit_model_name="DFF" num_regions="3">
+      <programming_clock port="prog_clk[0]" ccff_head_indices="0"/>
+      <programming_clock port="prog_clk[1]" ccff_head_indices="1,2"/>
+    </organization>
+  </configuration_protocol>
+  <connection_block>
+    <switch name="ipin_cblock" circuit_model_name="mux_tree_tapbuf"/>
+  </connection_block>
+  <switch_block>
+    <switch name="0" circuit_model_name="mux_tree_tapbuf"/>
+  </switch_block>
+  <routing_segment>
+    <segment name="L4" circuit_model_name="chan_segment"/>
+  </routing_segment>
+  <pb_type_annotations>
+    <!-- physical pb_type binding in complex block IO -->
+    <pb_type name="io" physical_mode_name="physical" idle_mode_name="inpad"/>
+    <pb_type name="io[physical].iopad" circuit_model_name="GPIO" mode_bits="1"/>
+    <pb_type name="io[inpad].inpad" physical_pb_type_name="io[physical].iopad" mode_bits="1"/>
+    <pb_type name="io[outpad].outpad" physical_pb_type_name="io[physical].iopad" mode_bits="0"/>
+    <!-- End physical pb_type binding in complex block IO -->
+    <!-- physical pb_type binding in complex block CLB -->
+    <!-- physical mode will be the default mode if not specified -->
+    <pb_type name="clb">
+      <!-- Binding interconnect to circuit models as their physical implementation, if not defined, we use the default model -->
+      <interconnect name="crossbar" circuit_model_name="mux_tree"/>
+    </pb_type>
+    <pb_type name="clb.fle[n1_lut4].ble4.lut4" circuit_model_name="lut4"/>
+    <pb_type name="clb.fle[n1_lut4].ble4.ff" circuit_model_name="DFFSRQ"/>
+    <!-- End physical pb_type binding in complex block IO -->
+  </pb_type_annotations>
+</openfpga_architecture>
diff --git a/openfpga_flow/regression_test_scripts/basic_reg_test.sh b/openfpga_flow/regression_test_scripts/basic_reg_test.sh
index 490cab089..bc437ec0b 100755
--- a/openfpga_flow/regression_test_scripts/basic_reg_test.sh
+++ b/openfpga_flow/regression_test_scripts/basic_reg_test.sh
@@ -25,6 +25,7 @@ run-task basic_tests/full_testbench/configuration_chain_use_setb $@
 run-task basic_tests/full_testbench/configuration_chain_use_set_reset $@
 run-task basic_tests/full_testbench/configuration_chain_config_enable_scff $@
 run-task basic_tests/full_testbench/multi_region_configuration_chain $@
+run-task basic_tests/full_testbench/multi_region_configuration_chain_2clk $@
 run-task basic_tests/full_testbench/fast_configuration_chain $@
 run-task basic_tests/full_testbench/fast_configuration_chain_use_set $@
 run-task basic_tests/full_testbench/smart_fast_configuration_chain $@
diff --git a/openfpga_flow/tasks/basic_tests/full_testbench/multi_region_configuration_chain_2clk/config/task.conf b/openfpga_flow/tasks/basic_tests/full_testbench/multi_region_configuration_chain_2clk/config/task.conf
new file mode 100644
index 000000000..74264971d
--- /dev/null
+++ b/openfpga_flow/tasks/basic_tests/full_testbench/multi_region_configuration_chain_2clk/config/task.conf
@@ -0,0 +1,45 @@
+# = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = =
+# Configuration file for running experiments
+# = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = =
+# timeout_each_job : FPGA Task script splits fpga flow into multiple jobs
+# Each job execute fpga_flow script on combination of architecture & benchmark
+# timeout_each_job is timeout for each job
+# = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = =
+
+[GENERAL]
+run_engine=openfpga_shell
+power_tech_file = ${PATH:OPENFPGA_PATH}/openfpga_flow/tech/PTM_45nm/45nm.xml
+power_analysis = true
+spice_output=false
+verilog_output=true
+timeout_each_job = 20*60
+fpga_flow=yosys_vpr
+
+[OpenFPGA_SHELL]
+openfpga_shell_template=${PATH:OPENFPGA_PATH}/openfpga_flow/openfpga_shell_scripts/write_full_testbench_example_script.openfpga
+openfpga_arch_file=${PATH:OPENFPGA_PATH}/openfpga_flow/openfpga_arch/k4_N4_40nm_multi_region_cc2clk_openfpga.xml
+openfpga_sim_setting_file=${PATH:OPENFPGA_PATH}/openfpga_flow/openfpga_simulation_settings/auto_sim_openfpga.xml
+openfpga_vpr_device_layout=--device 2x2
+openfpga_fast_configuration=
+
+[ARCHITECTURES]
+arch0=${PATH:OPENFPGA_PATH}/openfpga_flow/vpr_arch/k4_N4_tileable_40nm.xml
+
+[BENCHMARKS]
+bench0=${PATH:OPENFPGA_PATH}/openfpga_flow/benchmarks/micro_benchmark/and2/and2.v
+bench1=${PATH:OPENFPGA_PATH}/openfpga_flow/benchmarks/micro_benchmark/or2/or2.v
+bench2=${PATH:OPENFPGA_PATH}/openfpga_flow/benchmarks/micro_benchmark/and2_latch/and2_latch.v
+
+[SYNTHESIS_PARAM]
+bench_read_verilog_options_common = -nolatches
+bench0_top = and2
+bench0_chan_width = 300
+
+bench1_top = or2
+bench1_chan_width = 300
+
+bench2_top = and2_latch
+bench2_chan_width = 300
+
+[SCRIPT_PARAM_MIN_ROUTE_CHAN_WIDTH]
+end_flow_with_test=