diff --git a/consensus/ethash/difficulty.go b/consensus/ethash/difficulty.go
index 59c4ac7419..66a18059c6 100644
--- a/consensus/ethash/difficulty.go
+++ b/consensus/ethash/difficulty.go
@@ -52,8 +52,7 @@ func CalcDifficultyFrontierU256(time uint64, parent *types.Header) *big.Int {
 		- num = block.number
 	*/
 
-	pDiff := uint256.NewInt()
-	pDiff.SetFromBig(parent.Difficulty) // pDiff: pdiff
+	pDiff, _ := uint256.FromBig(parent.Difficulty) // pDiff: pdiff
 	adjust := pDiff.Clone()
 	adjust.Rsh(adjust, difficultyBoundDivisor) // adjust: pDiff / 2048
 
@@ -96,8 +95,7 @@ func CalcDifficultyHomesteadU256(time uint64, parent *types.Header) *big.Int {
 		- num = block.number
 	*/
 
-	pDiff := uint256.NewInt()
-	pDiff.SetFromBig(parent.Difficulty) // pDiff: pdiff
+	pDiff, _ := uint256.FromBig(parent.Difficulty) // pDiff: pdiff
 	adjust := pDiff.Clone()
 	adjust.Rsh(adjust, difficultyBoundDivisor) // adjust: pDiff / 2048
 
diff --git a/core/vm/instructions_test.go b/core/vm/instructions_test.go
index d17ccfab89..c881ba0aca 100644
--- a/core/vm/instructions_test.go
+++ b/core/vm/instructions_test.go
@@ -568,11 +568,11 @@ func BenchmarkOpSHA3(bench *testing.B) {
 	env.interpreter = evmInterpreter
 	mem.Resize(32)
 	pc := uint64(0)
-	start := uint256.NewInt()
+	start := new(uint256.Int)
 
 	bench.ResetTimer()
 	for i := 0; i < bench.N; i++ {
-		stack.pushN(*uint256.NewInt().SetUint64(32), *start)
+		stack.pushN(*uint256.NewInt(32), *start)
 		opSha3(&pc, evmInterpreter, &ScopeContext{mem, stack, nil})
 	}
 }
diff --git a/core/vm/logger_test.go b/core/vm/logger_test.go
index 9c936af36a..0bbfd44692 100644
--- a/core/vm/logger_test.go
+++ b/core/vm/logger_test.go
@@ -60,8 +60,8 @@ func TestStoreCapture(t *testing.T) {
 			Contract: contract,
 		}
 	)
-	scope.Stack.push(uint256.NewInt().SetUint64(1))
-	scope.Stack.push(uint256.NewInt())
+	scope.Stack.push(uint256.NewInt(1))
+	scope.Stack.push(new(uint256.Int))
 	var index common.Hash
 	logger.CaptureState(env, 0, SSTORE, 0, 0, scope, nil, 0, nil)
 	if len(logger.storage[contract.Address()]) == 0 {
diff --git a/go.mod b/go.mod
index 512d541f41..9a2e66e101 100644
--- a/go.mod
+++ b/go.mod
@@ -36,7 +36,7 @@ require (
 	github.com/graph-gophers/graphql-go v0.0.0-20201113091052-beb923fada29
 	github.com/hashicorp/golang-lru v0.5.5-0.20210104140557-80c98217689d
 	github.com/holiman/bloomfilter/v2 v2.0.3
-	github.com/holiman/uint256 v1.1.1
+	github.com/holiman/uint256 v1.2.0
 	github.com/huin/goupnp v1.0.1-0.20210310174557-0ca763054c88
 	github.com/influxdata/influxdb v1.8.3
 	github.com/jackpal/go-nat-pmp v1.0.2-0.20160603034137-1fa385a6f458
diff --git a/go.sum b/go.sum
index b6a27a2cf1..4cc4dbf20b 100644
--- a/go.sum
+++ b/go.sum
@@ -212,6 +212,8 @@ github.com/holiman/bloomfilter/v2 v2.0.3 h1:73e0e/V0tCydx14a0SCYS/EWCxgwLZ18CZcZ
 github.com/holiman/bloomfilter/v2 v2.0.3/go.mod h1:zpoh+gs7qcpqrHr3dB55AMiJwo0iURXE7ZOP9L9hSkA=
 github.com/holiman/uint256 v1.1.1 h1:4JywC80b+/hSfljFlEBLHrrh+CIONLDz9NuFl0af4Mw=
 github.com/holiman/uint256 v1.1.1/go.mod h1:y4ga/t+u+Xwd7CpDgZESaRcWy0I7XMlTMA25ApIH5Jw=
+github.com/holiman/uint256 v1.2.0 h1:gpSYcPLWGv4sG43I2mVLiDZCNDh/EpGjSk8tmtxitHM=
+github.com/holiman/uint256 v1.2.0/go.mod h1:y4ga/t+u+Xwd7CpDgZESaRcWy0I7XMlTMA25ApIH5Jw=
 github.com/hpcloud/tail v1.0.0/go.mod h1:ab1qPbhIpdTxEkNHXyeSf5vhxWSCs/tWer42PpOxQnU=
 github.com/huin/goupnp v1.0.1-0.20210310174557-0ca763054c88 h1:bcAj8KroPf552TScjFPIakjH2/tdIrIH8F+cc4v4SRo=
 github.com/huin/goupnp v1.0.1-0.20210310174557-0ca763054c88/go.mod h1:nNs7wvRfN1eKaMknBydLNQU6146XQim8t4h+q90biWo=